Harnessing the natural cellular process of autophagy to design powerful new medicines

Casma Therapeutics is harnessing the natural cellular process of autophagy to open vast new target areas for drug discovery and development. Casma uses several approaches to intervene at strategic points throughout the autophagy system to improve the cellular process of clearing out unwanted proteins, organelles and invading pathogens. By boosting autophagy, Casma expects to be able to arrest or reverse the progression of lysosomal storage disorders, muscle disorders, inflammatory disorders and neurodegeneration, among other indications.

Year Invested: 2018
Location: Cambridge, MA
Visit: www.casmatx.com/

Recent News

May 3, 2018
Third Rock Ventures Launches Casma Therapeutics with $58.5 Million Investment to Harness the Cellular Process of Autophagy to Develop Breakthrough Therapies

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Associated Team Members

Cary Pfeffer, M.D.

Frank T. Gentile, Ph.D.
Venture Partner

Robert Tepper, M.D.